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RYBELSUS® (semaglutide) tablets, 7 mg or 14 mg, are prescription drugs designed to decrease blood sugar (glucose) levels in adults with type 2 diabetes when combined with diet and exercise.

The use of RYBELSUS® as a first-line treatment for diabetes is not- recommended.

It is not clear whether RYBELSUS® can help those with pancreatitis.

People with type 1 diabetes should not take RYBELSUS®.

It is not known- whether RYBELSUS® is safe and effective in children under 18 years of age.

Rybelsus is a brand new oral medication for type 2 diabetes. Semaglutide is a general term for the same chemical that was previously only available as a once-a-week injection called Ozempic.

Ozempic and Victoza (Liraglutide) are peptides that are small proteins that are generally broken down in the gut and no longer work. It is Rybelsus engineering that allows it to be administered orally without fragmentation and still without effect. The maximum dose of Ozempic injectable is 1 mg, and Rybelsus has a maximum dose of 14 mg. Different doses indicate that large amounts of Rybelsus are still broken down in the intestines before ingestion.

Rybelsus comes in three different dosages;




What is the Rybelsus starting dose

In the first month, the initial dose of Rybelsus is 3 mg once daily (30 days). If the client can tolerate the drug after this period, the dose should be increased to 7 mg daily.

If your blood sugar remains high after 30 days on a 7 mg dose, your Rybelsus dose may be increased to 14 mg once daily. Two Rybelsus 7 mg tablets should not be taken to obtain a 14 mg dose to prevent confusion; Instead, the 14 mg tablet- should be taken alone.

Semaglutide is a synthetic form of a peptide similar to glucagon one (1) or GLP-1, a natural human hormone designed to be less likely to be broken down and have a longer duration of action.

GLP-1 is produced by everyone, whether they have diabetes or not. GLP-1 is an important hormone that helps regulate blood sugar levels as well as our appetite and weight.

How does Rybelsus work?

Rybelsus is 94% identical to GLP-1 in humans. It can act in a similar way to natural GLP-1 in the body and therefore have very similar effects, for example:

When your blood sugar is high, your insulin secretion increases.

Less glucose is released into the circulation from liver stores.

Decreased appetite.

How is Rybelsus (Semaglutide) different from GLP-1?

GLP-1 is a hormone that everyone produces naturally. Rybelsus (Semaglutide) is a synthetic GLP-1 product that has 94% of the same structure as human GLP-1. The structure of semaglutide has been changed to prevent it from being broken down by a blood enzyme called dipeptidyl peptidase-4 or DPP-4.

Rybelsus, like other GLP-1 drugs (Ozempic, Trulicity, Victoza, Bydureon, and Byetta), works by mimicking the body's natural hormone GLP-1 in response to rising blood sugar.

Ozempic is an injectable form of semaglutide and is an example of GLP-1 once a week. 

Rybelsus is given once daily and is the only oral tablet of GLP-1, whereas Ozempic is the injectable form of semaglutide and is an example of GLP-1 once a week.

 Truth is another example of the old working GLP-1 (generic name Dulaglutide).

DPP-4 inhibitors are drugs that block the function of DPP-4 and have long been used to treat type 2 diabetes. 

They increase the amount of GLP-1 in the body by small amounts by inhibiting the enzyme that breaks down natural GLP. -1. (Dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes). 

DPP-4 inhibitors include the following:

sitagliptin (Januvia)

valdagliptin (Galvus)

saxagliptin (Onglyza)

linagliptin (Tradjenta)

alogliptin (Nesina)

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