Contrave combines two drugs currently on the market: the antidepressant bupropion (Wellbutrin) and the antidepressant drug naltrexone. The new drug will contain a warning box because it contains bupropion, which warns- doctors and patients about the increased risk of suicidal ideation with antidepressants.
Although weight-loss experts believe that all three drugs work- in the same way, Contrave is a good supplement because not all weight loss drugs have the same effect on everyone.
Contrave (naltrexone/bupropion) is a medicine that combines two medicines. Bupropion is an inhibitor of dopamine and norepinephrine reuptake, and naltrexone is an opioid antagonist. To reduce the need to eat, they work together in the areas of your brain that are responsible for regulating appetite and reward systems.
In one of the largest_ Contrave clinical trials to date, obese and overweight people who received treatment for up to 56 weeks lost an average of 12 pounds (or about 5% of their body weight) compared to 3 pounds. pounds (or 1%). body weight). their body weight) in those taking a placebo. In addition, both groups followed a low-calorie diet, exercised regularly, and received behavioral counseling.
To put it in context, I calculated that a 220-pound person taking Contrave would lose a total of 12 pounds in a year: 9 pounds from a pill and 3 pounds from diet and exercise.
In a separate study, obese and overweight people who took Contrave for up to one year lost an average of 18 pounds (or 8% of body weight) compared with 11 pounds (5% of body weight) in the placebo group.
In addition, both groups received a low-calorie diet, exercised regularly, and received behavioral advice. As a result, Contrave helped lose another 7 pounds.
The results were less impressive for_ diabetics. Overweight adults with Contrave disease up to -the age of one year lost an average of 9 kilograms or 4% of their body weight, compared to 4 kilograms or 2% of their body weight for placebo recipients. Contrave only helps people lose five(5) extra pounds in this situation.
Additionally, not everyone who takes Contrave will lose weight: in one study, about 42% of people who took Contrave lost 5% or more of their body weight, and only 17% of those who took a placebo.